Genome-scale ChIP-chip analysis using 10,000 human cells
نویسندگان
چکیده
منابع مشابه
Genome-scale ChIP-chip analysis using 10,000 human cells.
The technique of chromatin immunoprecipitation (ChIP) is a powerful method for identifying in vivo DNA binding sites of transcription factors and for studying chromatin modifications. Unfortunately, the large number of cells needed for the standard ChIP protocol has hindered the analysis of many biologically interesting cell populations that are difficult to obtain in large numbers. New ChIP me...
متن کاملChIP-chip comes of age for genome-wide functional analysis.
In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of c...
متن کاملWhole-genome ChIP–chip analysis of Dorsal, Twist, and Snail
data Supplementary http://www.genesdev.org/cgi/content/full/21/4/385/DC1 "Supplemental Research Data" References http://www.genesdev.org/cgi/content/full/21/4/385#References This article cites 33 articles, 18 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the
متن کاملChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes.
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed at minimizing false-positive transcription factor targets. We present a model with improved sensitivity in detecting binding events from ChIP-on-chip data. Its applicat...
متن کاملComparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq
MOTIVATION ChIP-chip and ChIP-seq technologies provide genome-wide measurements of various types of chromatin marks at an unprecedented resolution. With ChIP samples collected from different tissue types and/or individuals, we can now begin to characterize stochastic or systematic changes in epigenetic patterns during development (intra-individual) or at the population level (inter-individual)....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioTechniques
سال: 2007
ISSN: 0736-6205,1940-9818
DOI: 10.2144/000112625